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Infusion of epoprostenol (prostacyclin, PGI2) in human subjects leads to a rise in pulse rate, a fall in diastolic pressure and a rise in pulse pressure.In three healthy subjects these responses to PGI2were identical before and after 30 min continuous cigarette smoking, and demonstrate that the attenuation of the PGI2 response by smoking reported in rats does not occur in healthy humans.
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Hassan et al. (1982) studied this question.
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