If a given dose of a drug produced the same plasma concentration in all patients there would be no need to measure the plasma concentration of the drug. However, people varx considerably in the extent to which they absorb, distribute, and e' i nate drugs. Tenfold or even greater differences tg11 | | |in steady state plasma concentrations have been found among patients 0 .t treated with the same dose of important drugs such as phenytoin, warfarin, and digoxin. The following are some of the many reasons for these differences.
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Aronson et al. (1992) studied this question.