This review summarizes the mechanisms and evolutionary trends of reversible myosin phosphorylation in non-muscle and smooth muscle cells.
Summarizes myosin phosphorylation mechanisms in smooth muscle; extends evolutionary insights while leaving clinical cardiovascular applications open.
Reversible phosphorylation of myosin subunits is observed in almost all eukaryotic cells. The data concerning sites and effects of phosphorylation on actin-activated ATPase activity of myosin and on its filament formation are described. These observations are discussed in terms of possible evolutionary trends and rules which may govern the process of myosin phosphorylation.
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Jacek Kuźnicki (1986) studied this question.
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