This study demonstrates the presence of a troponin-like complex in bovine brain cortex that regulates actomyosin ATPase activity in a calcium-dependent manner.
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May extend troponin-like Ca2+ regulation to brain; leaves open neuronal roles, requiring in vivo validation.
A troponin-like complex has been isolated from bovine brain cortex. This tropinin-like complex, with brain tropomyosin, confers Ca2+ sensitivity to the actin-activated myosin adenosinetriphosphatase (ATP phosphohydrolase, EC 3.6.1.3). That is, the Mg2+-stimulated ATPase activity generated by the interaction of purified muscle actin with muscle myosin is inhibited in the absence of Ca2+ but not in the presence of Ca2+ as a result of the addition of both brain tropomyosin and troponin-like complex. The troponin-like complex contains three components, one of which is similar in molecular weight to the troponin-T of skeletal actomyosin.
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Mahendran et al. (1977) studied this question.
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