Key result
Quercetin demonstrates vascular protective effects in preclinical models, warranting further human validation.
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A recent paper in the Canadian Journal of Physiology and Pharmacology has shown that quercetin has a vascular protective effect associated with eNOS up-regulation, blood GSH redox ratio, and reduction of oxidative stress. Recent reports have recommended the consumption of quercetin, as it may contribute to a reduction in the risk of cardiovascular disease. However, the mechanisms by which quercetin exerts its action have not been fully elucidated. The majority of these mechanisms have been identified with models using animals treated with quercetin, and relatively few have been corroborated in human studies, which indicates the need for further investigation.
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Salvatore Chirumbolo (2012) conducted a review in Cardiovascular disease. Quercetin was evaluated. Quercetin shows vascular protective effects primarily in animal models, highlighting the need for further investigation to corroborate these mechanisms in human studies.
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