Polycystic Ovary Syndrome and Periodontitis: Unraveling the Oral-systemic Link

Women of reproductive age commonly experience endocrine and gynecological disorders, with polycystic ovary syndrome (PCOS) being the most common. Recent evidence suggests a two-way link between PCOS and periodontitis, driven by chronic low-grade systemic inflammation. This review explores the underlying pathophysiology connecting these conditions, emphasizing pro-inflammatory cytokines and matrix metalloproteinases. Moreover, advancements in artificial intelligence and machine learning are discussed for their potential in early, noninvasive diagnosis of PCOS and periodontitis. Understanding these links could enhance patient management and facilitate the development of predictive diagnostic models.