Learning Objectives After completing this course, the reader will be able to: Define the principal metabolites in the brain evaluated by proton spectroscopy. Identify factors that can potentially interfere with obtaining spectroscopy results. Assess the results from a patient's single or multivoxel spectroscopy analysis. Access and take the CME test online and receive 1 hour of AMA PRA category 1 credit at CME.TheOncologist.com Proton nuclear magnetic resonance spectroscopy (1H-NMRS) is a noninvasive in vivo technique that utilizes conventional MR imaging hardware to obtain biochemical information from a discrete volume of tissue after suppression of the water signal. MR spectroscopy coupled with conventional MR imaging allows correlation of structural changes with biochemical processes in tissues by measuring specific metabolites present in brain tissue. NMRS is commonly used in the evaluation of patients with brain tumors. This article reviews the basic principles of spectroscopy and its use in evaluating pediatric patients with brain tumors.
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