What question did this study set out to answer?

This study aims to determine if 3D radiomic texture analysis of quantitative muscle MRI can improve the differentiation between myogenic and neurogenic neuromuscular diseases.

August 3, 2026European Journal of NeurologyOpen Access

3D Radiomic Texture Analysis of Quantitative Muscle MRI Enhances the Distinction Between Myotonic Dystrophy Type 1 and Charcot–Marie‐Tooth Neuropathy Type 1A : A Proof‐of‐Concept Study

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Authors

LIL. IterbekeAllen Institute for Brain Science LHLotte HuysmansKU Leuven KBKobe BampsUniversitair Ziekenhuis Leuven

Discussion

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Implication

Proof-of-concept study shows 3D radiomic texture analysis improves distinction of diseases in patients with neuromuscular disorders.

Key Points

This study aims to determine if 3D radiomic texture analysis of quantitative muscle MRI can improve the differentiation between myogenic and neurogenic neuromuscular diseases.
Included 33 adults with myotonic dystrophy type 1 (DM1), 33 with Charcot-Marie-Tooth neuropathy type 1A (CMT1A), and 33 healthy controls.
Performed quantitative muscle MRI on a 3T Philips Achieva system using a 6-point Dixon sequence.
Extracted macroscopic and micro-spatial radiomic features from 28 lower limb muscles for analysis.
Both DM1 and CMT1A had higher PDFF(%) in lower limb muscles than controls (p < 0.001).
DM1 predominantly affected the posterior compartment, while CMT1A targeted the anterolateral compartment with steeper disto-proximal fat gradients (p < 0.05).
3D radiomic texture analysis showed CMT1A had higher entropy and contrast but lower homogeneity compared to DM1.

Cite This Study

Iterbeke et al. (2026) studied this question.

synapsesocial.com/papers/6a70402275942ff7265e4d23 https://doi.org/10.1111/ene.70719

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August 3, 2026European Journal of NeurologyOpen Access

3D Radiomic Texture Analysis of Quantitative Muscle MRI Enhances the Distinction Between Myotonic Dystrophy Type 1 and Charcot–Marie‐Tooth Neuropathy Type 1A : A Proof‐of‐Concept Study

View Full Paper

Ask AI

Bookmark

Authors

LIL. IterbekeAllen Institute for Brain Science LHLotte HuysmansKU Leuven KBKobe BampsUniversitair Ziekenhuis Leuven

Discussion

Member takes

Implication

Proof-of-concept study shows 3D radiomic texture analysis improves distinction of diseases in patients with neuromuscular disorders.

Key Points

This study aims to determine if 3D radiomic texture analysis of quantitative muscle MRI can improve the differentiation between myogenic and neurogenic neuromuscular diseases.
Included 33 adults with myotonic dystrophy type 1 (DM1), 33 with Charcot-Marie-Tooth neuropathy type 1A (CMT1A), and 33 healthy controls.
Performed quantitative muscle MRI on a 3T Philips Achieva system using a 6-point Dixon sequence.
Extracted macroscopic and micro-spatial radiomic features from 28 lower limb muscles for analysis.
Both DM1 and CMT1A had higher PDFF(%) in lower limb muscles than controls (p < 0.001).
DM1 predominantly affected the posterior compartment, while CMT1A targeted the anterolateral compartment with steeper disto-proximal fat gradients (p < 0.05).
3D radiomic texture analysis showed CMT1A had higher entropy and contrast but lower homogeneity compared to DM1.

Cite This Study

Iterbeke et al. (2026) studied this question.

synapsesocial.com/papers/6a70402275942ff7265e4d23 https://doi.org/10.1111/ene.70719

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