Letter critiques the classification of epidermolysis bullosa simplex as an epidermal differentiation disorder, suggesting misclassification implications.
This letter is linked to the recent case report, “Late-onset PLEC-nEDD (epidermolysis bullosa simplex-Ogna) published in a Chinese patient” in Clinical and Experimental Dermatology. Here, epidermolysis bullosa simplex is designated as an Epidermal differentiation disorder (EDD). This is scientifically imprecise, since plectin, the defective protein, is a major cytolinker protein involved in the anchorage of the cytoskeleton. Clinically and pathophysiologically, epidermolysis bullosa belongs to the broad group of epidermolysis bullosa and the disorders with skin fragility.
No takes yet. Share an insight, caveat, or question.
Has et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: