Amino Acid Deficiency Secondary to Continuous Venovenous Hemofiltration in Acute Decompensation of Organic Acidemias: An Anabolic Dead End?

Chloé Grosyeux; Noémie Cammiciotto; Élise Jeannesson; Eva Feigerlova; Valentine Villada; Camille Wicker; Michael Levy; Manuel Schiff; Apolline Imbard; David Coelho; François Feillet; Arnaud Wiedemann

doi:10.1097/cce.0000000000001413

August 1, 2026Critical Care ExplorationsOpen Access

Amino Acid Deficiency Secondary to Continuous Venovenous Hemofiltration in Acute Decompensation of Organic Acidemias: An Anabolic Dead End?

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Key Points

This study evaluates how continuous renal replacement therapy affects amino acid levels in patients with acute organic acidemias and the potential benefits of supplementation.
Multicenter retrospective observational study conducted in pediatric intensive care units (PICUs).
Patients with confirmed organic acidemias undergoing continuous renal replacement therapy (CRRT) were analyzed.
Quantitative measurements of plasma amino acids were taken before and after CRRT.
Before CRRT, 31% of plasma amino acids were low; after CRRT, this increased to 69% (p < 0.0001).
Lactate levels rose significantly from 2.2 mmol/L before CRRT to 5.3 mmol/L after CRRT (p = 0.0065).
In one patient receiving amino acid supplementation, the proportion of low plasma amino acids dropped from 65% to 15% after CRRT.

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Implication

Multicenter retrospective observational study evaluates amino acid depletion and supplementation during CRRT in organic acidemias, indicating potential benefits of supplementation.

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Cite This Study

Grosyeux et al. (2026) studied this question.

synapsesocial.com/papers/6a70405975942ff7265e5572 https://doi.org/10.1097/cce.0000000000001413

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Amino Acid Deficiency Secondary to Continuous Venovenous Hemofiltration in Acute Decompensation of Organic Acidemias: An Anabolic Dead End?

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Amino Acid Deficiency Secondary to Continuous Venovenous Hemofiltration in Acute Decompensation of Organic Acidemias: An Anabolic Dead End?

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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