Why the study?
Does dietary salt intake affect all-cause mortality in high-risk patients with advanced type 2 diabetes?
Does dietary salt intake affect all-cause mortality in high-risk patients with advanced type 2 diabetes?
In high-risk patients with advanced type 2 diabetes, all-cause mortality remains inversely associated with 24-hour urinary sodium excretion even after adjusting for multiple confounders.
We thank Lambers Heerspink et al. (1) for their comments and agree that observational studies are prone to confounding. We also agree that our study population represents high-risk patients with advanced type 2 diabetes and does not represent the general population. Importantly, after adjusting for factors independently associated with all-cause mortality including age, sex, duration of diabetes, atrial fibrillation, the presence and severity of chronic kidney disease (estimated glomerular filtration rate and log albumin excretion rate), and parameters associated with 24-h urinary sodium excretion (24hUNa) including BMI, all-cause mortality remained inversely associated …
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Ekinci et al. (2011) studied this question.
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