Why the study?
Diagnostic algorithms for obstructive macrovascular CAD do not exclude microvascular angina, potentially leading to false reassurance of symptomatic patients with functionally significant non-obstructive coronary vascular disease.
Population
Women and men aged 45 years and older with chest pain referred to an outpatient clinic
Comparison
Coronary CT angiography and adenosine stress cardiac MRI evaluation
Design
Prospective diagnostic study protocol
Authors
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Current CAD algorithms risk false reassurance in microvascular angina (esp. women); leaves open need for refined inclusive protocols in prospective studies.
The ARGUS study is designed to estimate the prevalence of macrovascular and microvascular coronary disease in patients with chest pain to develop a machine-learning decision-support tool for imaging referral.
Groepenhoff et al. (2020) studied this question.
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