Caldesmon and skeletal muscle troponin T share a common antigenic determinant, suggesting a common structure in their tropomyosin-binding sites.
No clinical implications; leaves open whether shared epitopes affect tropomyosin regulation in human muscle.
Caldesmon and troponin are known to control actin-myosin interaction in smooth and striated muscle. We showed that polyclonal antibodies to smooth muscle caldesmon150 cross-react with non-muscle caldesmon77 and with skeletal muscle troponin T. The epitope recognized by caldesmon antibodies is located in the CB 2 peptide [residues 71-151] of troponin T. It is supposed that the observed cross-reactivity is due to the common structure of the tropomyosin-binding site of caldesmon and troponin T.
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Shirinsky et al. (1989) studied this question.
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