What question did this study set out to answer?

August 1, 1968Circulation ResearchOpen Access

Distribution of Sympathetic Fibers in the Left Ventricular Epicardial Plexus of the Dog

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Population

14 dogs under chloralose anesthesia

Comparison

Segmental chemical epicardiectomy with… vs Baseline (prior to epicardiectomy)

Design

Preclinical

Authors

WGW. P. GeisSt. Joseph Hospital MKMichael P. KayeUniversity of Michigan

Discussion

Member takes

Implication

Does not support clinical epicardiectomy or denervation changes; leaves open translational validation of base-to-apex sympathetic mapping.

Key Points

This study aims to investigate the distribution of sympathetic fibers in the left ventricular epicardial plexus and their role in myocardial contractile response.
Measured myocardial contractile force in 14 dogs under chloralose anesthesia before and after epicardiectomy.
Stimulated the stellate ganglia and recorded myocardial contractile responses.
Conducted segmental chemical epicardiectomy to assess effects on contractile responses.
Epicardiectomy led to loss of contractile response in specific left ventricular areas (per-arm loss of response noted).
Demonstrated significant projections of sympathetic fibers from both left and right stellate ganglia.
Sympathetic fiber pathways are oriented from base to apex of the left ventricle, interrupted by epicardial destruction.

Structured PICO

Population

14 dogs under chloralose anesthesia

Intervention

Segmental chemical epicardiectomy with electrical stimulation of the stellate ganglia

Comparator

Baseline (prior to epicardiectomy)

Outcome

Myocardial contractile force in five areas of the left ventriclesurrogate

Demonstrates the specific base-to-apex orientation and epicardial distribution of sympathetic nerve fibers in the canine left ventricle.

Cite This Study

Geis et al. (1968) studied this question.

synapsesocial.com/papers/6a7045e0a2d7cf2e39c2a481 https://doi.org/10.1161/01.res.23.2.165

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Implication

Does not support clinical epicardiectomy or denervation changes; leaves open translational validation of base-to-apex sympathetic mapping.

Distribution of Sympathetic Fibers in the Left Ventricular Epicardial Plexus of the Dog

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Distribution of Sympathetic Fibers in the Left Ventricular Epicardial Plexus of the Dog

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider