Why the study?
The study was conducted to explore the relationship between Lactobacillus and prognosis in acute myocardial infarction patients treated with emergency PCI, as well as its correlation with clinical parameters.
Do higher levels of stool Lactobacillus improve prognosis and correlate with clinical parameters in patients with acute myocardial infarction treated by emergency PCI?
Do higher levels of stool Lactobacillus improve prognosis and correlate with clinical parameters in patients with acute myocardial infarction treated by emergency PCI?
Higher levels of stool Lactobacillus are associated with reduced inflammation, less myocardial damage, and better outcomes in STEMI patients, particularly older male smokers with severe cardiac impairment.
Lactobacillus levels may aid post-PCI risk stratification in AMI; leaves open whether microbiome modulation alters outcomes.
OBJECTIVE: To explore the relationship between Lactobacillus and prognosis of acute myocardial infarction (AMI) patients treated by percutaneous coronary intervention (PCI) and its correlation with clinical parameters. METHODS: Consecutive patients with AMI in the coronary care unit of Tianjin Chest Hospital in China who received emergency PCI between July 2017 and December 2018 were enrolled. Subjects' fecal 16S rDNA gene sequencing data were analyzed and subjects were categorized into low, medium and high level groups according to stool Lactobacillus measurements. The primary endpoints were major adverse cardiac events. Cox regression analysis was used to analyze the relationship between Lactobacillus and prognosis. Spearman correlation analysis and trend tests were used to assess the relationship between Lactobacillus and the clinical indicators. Lactobacillus was a protective factor for male smokers aged over 60 years whose brain natriuretic peptide was over 1,000 pg/mL. Spearman correlation analysis showed that Lactobacillus correlated negatively with white blood cells, neutrophils, high-sensitivity C-reactive protein, TroponinT, creatine kinase, creatine kinase-MB and brain natriuretic peptide (downward trend), and correlated positively with left ventricular ejection fraction (upward trend). CONCLUSIONS: This study is the first to reveal the correlation between Lactobacillus and inflammation and myocardial damage after STEMI. STEMI patients, especially male smokers aged over 60 years with severe impairment of cardiac function, have better outcomes with high levels of Lactobacillus, suggesting new therapeutic strategies for improving the prognosis and quality of life of AMI patients.
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Cai et al. (2022) studied this question.
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