Key result
Corticosteroids plus anti-NTM therapy resolve massive immune-mediated pericardial effusion in anti-IFN-γ autoantibody syndrome.
Why the study?
Pericardial effusion as a direct manifestation of anti-interferon-gamma autoantibodies syndrome is rarely reported.
Case Report (n=1)
This case highlights that massive pericardial effusion can be a rare, immune-mediated complication of anti-IFN-γ autoantibodies syndrome, which responds well to corticosteroid therapy.
May support adjunctive corticosteroids in anti-IFN-γ autoantibody-associated pericardial effusion; leaves open prospective validation.
Background Anti-interferon-gamma (IFN-γ) autoantibodies (AIGAs) syndrome is an emerging adult-onset immunodeficiency (AOID) associated with opportunistic infections and immune dysregulation. Pericardial effusion as a direct manifestation of this syndrome is rarely reported. Case presentation A 46-year-old man with a history of Talaromyces marneffei (TM) infection and clinically suspected pulmonary nontuberculous mycobacterial (NTM) disease presented with rapid-onset massive pericardial effusion. The NTM diagnosis was not microbiologically confirmed, as the patient declined bronchoscopy. Pericardial fluid analysis revealed a high inflammatory cell count and an anti-IFN-γ autoantibody titer of 1:2500, identical to serum, despite a negative microbiological workup and no definitive evidence of malignancy on available cytological evaluation. The patient responded well to corticosteroids and anti-NTM therapy, with complete resolution of effusion. Conclusion This case highlights pericardial effusion as a potential immune-mediated complication of AIGAs syndrome. Clinicians should consider this diagnosis in patients with unexplained serositis and a history of opportunistic infections.
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Chen et al. (2026) conducted a case report in Anti-IFN-γ autoantibodies syndrome with pericardial effusion (n=1). Corticosteroids and anti-NTM therapy was evaluated on Resolution of pericardial effusion. Corticosteroid therapy combined with anti-NTM treatment resulted in complete resolution of massive immune-mediated pericardial effusion in a patient with anti-IFN-γ autoantibodies syndrome.
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