Human blood leukocytes, following incubation with a purified endotoxin derived from Proteus vulgaris or with heat-killed Staphylococcus albus cells, release a pyrogen that produces fever in rabbits. This material is clearly separable from bacterial endotoxin, and has properties similar to those described for leukocyte pyrogen produced by rabbit granulocytes.
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Bodel et al. (1966) studied this question.