Cellulose-bound Peptide Arrays: Preparation and Applications

The way of the development of the cellulose-bound peptide arrays leads via the synthesis of oligonucleotides on cellulose pieces (Frank et al., 1983) and multiple peptide synthesis on cellulose paper discs in columns (Frank and Doring, 1988). Probably inspired by the addressability of the multipin method (Geysen et al., 1984), Ronald Frank and co-workers developed SPOT synthesis and first presented the method in 1990 at the 21st European Peptide Symposium (Frank et al., 1991). Today,