A balancing act: Complementary catalytic systems are described, in which the reactivity/selectivity balance in PdII-catalyzed ortho-CH olefination can be modulated to enable sequential CH functionalization for the rapid preparation of 1,2,3-trisubstituted arenes 1. Additionally, a rare example of iterative CH activation, in which a newly installed functional group directs subsequent CH activation has been demonstrated (2).
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Engle et al. (2010) studied this question.
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