Why the study?
Little is known about the natural history of primary hypokalemic periodic paralysis.
Population
25 men and 12 women with HypoPP-causing mutations in CACNA1S
Design
3-year follow-up study
Follow-up
Median 42 months (range 26-52)
Authors
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MRI detects subclinical progression in HypoPP; leaves open its role in guiding therapy or predicting outcomes.
Hypokalemic periodic paralysis can manifest as a progressive myopathy with increasing muscle fat replacement and weakness, even in patients who do not experience attacks of paralysis.
Holm‐Yildiz et al. (2023) studied this question.
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