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Atherosclerosis vaccines show potential to reduce plaque progression in preclinical models.
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Substantial data from experimental and clinical investigation support the role of immune-mediated mechanisms in atherogenesis, with immune systems responding to many endogenous and exogenous antigens that play either proatherogenic or atheroprotective roles. An active immunization strategy against many of these antigens could potentially alter the natural history of atherosclerosis. This review mainly focuses on the important studies on the search for antigens that have been tested in vaccine formulations to reduce atherosclerosis in preclinical models. It will also address the opportunities and challenges associated with potential clinical application of this novel therapeutic paradigm.
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Chyu et al. (2017) conducted a review in Atherosclerosis. Atherosclerosis vaccine formulations was evaluated. Active immunization strategies against various antigens show potential to reduce atherosclerosis in preclinical models, highlighting a novel therapeutic paradigm for clinical application.
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