Chronic giardiasis in a patient with suspected chronic variable immunodeficiency – a retrospective case report

<ns3:p>The study presents a case report of a patient with chronic giardiasis and suspected common variable immunodeficiency (CVID). The patient, who had hypogammaglobulinemia of IgG, IgA, and IgM, reported gastrointestinal symptoms such as abdominal pain, vomiting, and diarrhea after consuming certain foods. The patient was diagnosed with Giardia intestinalis infection, which persisted despite multiple pharmacological treatments. Endoscopic examinations revealed ileal polyps and features of microscopic enteritis, while imaging studies showed mesenteric lymph node enlargement. Due to the chronic nature of the infection and the coexisting immune deficiency, the diagnosis of giardiasis was extended to include detailed molecular investigations. This case highlights the diagnostic and therapeutic challenges in patients with immune deficiencies and chronic parasitic infections.</ns3:p>