Why the study?
Does goal-directed fluid therapy improve outcomes compared to traditional liberal or restrictive fluid strategies in perioperative patients?
Does goal-directed fluid therapy improve outcomes compared to traditional liberal or restrictive fluid strategies in perioperative patients?
Goal-directed fluid therapy is superior to liberal fluid administration but may not offer additional benefits over a restrictive strategy within an enhanced recovery pathway.
May not outperform restrictive strategies in optimized ERAS; leaves open ideal GDFT monitors and targets.
Goal-directed fluid therapy (GDFT) seeks to improve outcomes through individualized optimization of oxygen delivery using IV fluid and vasoactive infusions. Trials of GDFT show clinical benefits over traditional liberal fluid administration, but fail to demonstrate benefits when compared to a restrictive strategy within an optimized enhanced recovery protocol. The ideal monitors, hemodynamic goals, and fluid administration strategy are not well established but may be less important than rational application of thoughtful fluid management strategies.
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Manning et al. (2017) studied this question.
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