Papulacandins - The relationship between chemical structure and effect on glucan synthesis in yeast.

Papulacandin B inhibits glucan biosynthesis in cells of Saccharomyces cerevisiae and Candida albicans. Biological studies with a series of papulacandin derivatives showed that the short fatty acid chain and the galactose residue are not required for activity at the target site, but that they can affect penetration. On the other hand, the long fatty acid residue is essential for biological activity.