Key result
Thrombolysis for ischemic stroke linked to ~4-point higher hospital mortality in community practice.
Cohort
Yes
The authors performed a retrospective cohort comparison using the Nationwide Inpatient Sample for 1999 through 2002 of acute ischemic stroke admissions. Mortality was compared based on the use of thrombolysis. Hospital mortality was significantly greater for the thrombolysis cohort (10.1% vs 5.8%) as was the rate of secondary intracranial hemorrhage (4.2% vs 0.4%). US community experience in the use of thrombolysis has higher rates of complications and mortality than in controlled clinical trials.
No takes yet. Share an insight, caveat, or question.
Dubinsky et al. (2006) conducted a cohort in Acute ischemic stroke. Thrombolysis vs. No thrombolysis was evaluated on Hospital mortality. Thrombolysis for acute ischemic stroke in US community practice was associated with higher hospital mortality (10.1% vs 5.8%) and secondary intracranial hemorrhage (4.2% vs 0.4%).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: