A 7-year-old boy with Prader-Labhart-Willi syndrome was found to have the following karyotype: 45, XY, t(15;17)(q13;p13). This translocation is the first reported in this syndrome. The patient’s parents have normal karyotypes. The association of this syndrome with major chromosome aberrations is briefly reviewed and its etiological relevance is discussed.
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Cavalli et al. (1982) studied this question.