Clinical Atlas of Human Chromosomes

lished biochemical data about Singapore syndrome.(Blood glucose concentrations were less than 2-8 mmol/l in 6 of 14, 7 of 18 had a two to three fold rise in transaminase activity, 2 of 12 had coagulation abnormalities, but blood ammonia values were not reported.)Seizures, the most common presentation of Singapore syndrome, occurred in 48% (11 of 23) of my Reye's syndrome patients.From a study of their published work and in personal discussions several years ago, it is my impression that Aiyathurai and colleagues have described a separate, quite distinct syndrome, possibly more akin to the febrile seizure than to Reye's syndrome.The differences, particularly in clinical presentation, laboratory data, and prognosis, given the conservative approach to management, make it unlikely that Singapore syndrome is a subgroup of the syndrome described by Reye et al.8Finally, a note of caution to those who continue to use a 'wait and see' policy in stage II Reye's syndrome; it is an unpredictable and unforgiving disorder.Despite intensive care and vigorous measures to control intracranial pressure using 'prophylactic' hyperventilation etc, 25% of the Belfast patients died or incurred severe, permanent neurological damage.