What question did this study set out to answer?

To report a case of infantile histoplasmosis and examine how intracellular fungal invasion of mononuclear cells contributes to systemic disease pathology.

March 1, 1934The American journal of tropical medicine.

A Case of Histoplasmosis of Darling in an Infant

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Authors

KDKatharine DoddUniversity of Arkansas at Little Rock ETEdna H. TompkinsUnited States Department of the Army

Discussion

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Implication

Case report demonstrates antemortem detection of Histoplasma in mononuclear cells in an infant, suggesting infected phagocytes drive severe multi-organ vascular and marrow complications.

Key Points

To report a case of infantile histoplasmosis and examine how intracellular fungal invasion of mononuclear cells contributes to systemic disease pathology.
Clinical and microscopic evaluation of peripheral blood collected during life from an infant in Tennessee (N=1).
Pathological examination and species confirmation of the intracellular organism by an academic pathology department.
Microscopic analysis of blood during life identified the characteristic fungal parasite situated within circulating large mononuclear cells.
Involvement of parasitized mononuclear cells accounted for extensive bone marrow invasion, pulmonary alveolar collapse, vascular occlusion, and erythrocyte destruction.

Cite This Study

Dodd et al. (1934) studied this question.

synapsesocial.com/papers/6a70518dc92390ac2d07bf7a https://doi.org/10.4269/ajtmh.1934.s1-14.127

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March 1, 1934The American journal of tropical medicine.

A Case of Histoplasmosis of Darling in an Infant

View Full Paper

Ask AI

Bookmark

Authors

KDKatharine DoddUniversity of Arkansas at Little Rock ETEdna H. TompkinsUnited States Department of the Army

Discussion

Member takes

Implication

Case report demonstrates antemortem detection of Histoplasma in mononuclear cells in an infant, suggesting infected phagocytes drive severe multi-organ vascular and marrow complications.

Key Points

To report a case of infantile histoplasmosis and examine how intracellular fungal invasion of mononuclear cells contributes to systemic disease pathology.
Clinical and microscopic evaluation of peripheral blood collected during life from an infant in Tennessee (N=1).
Pathological examination and species confirmation of the intracellular organism by an academic pathology department.
Microscopic analysis of blood during life identified the characteristic fungal parasite situated within circulating large mononuclear cells.
Involvement of parasitized mononuclear cells accounted for extensive bone marrow invasion, pulmonary alveolar collapse, vascular occlusion, and erythrocyte destruction.

Cite This Study

Dodd et al. (1934) studied this question.

synapsesocial.com/papers/6a70518dc92390ac2d07bf7a https://doi.org/10.4269/ajtmh.1934.s1-14.127

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