Cutaneous lesions of letterer-siwe disease.Electron microscopic study

The fine structure of the cells in the cutaneous lesions of Letterer-Siwe disease is presented. The occurrence of peculiar bodies is documented and these structures are compared with those described in other forms of the disorder and in the Langerhans cell of the epidermis. The authors suggest that these granules originate from the cytoplasmic membrane and the membranous channels of the endoplasmic reticulum or Golgi system.