Why the study?
Does peritoneal lavage with tetracycline solution reduce postoperative infection rates in patients undergoing elective and emergency intestinal operations?
Does peritoneal lavage with tetracycline solution reduce postoperative infection rates in patients undergoing elective and emergency intestinal operations?
Tetracycline peritoneal lavage in addition to systemic antibiotics significantly reduces postoperative infection rates in patients undergoing intestinal operations.
Supports tetracycline peritoneal lavage plus systemic antibiotics in intestinal operations; extends RCT evidence for intraoperative infection prevention.
A prospective randomized trial was performed to determine the value of tetracycline lavage in addition to systemic antibiotic prophylaxis in 159 patients undergoing elective and emergency intestinal operations. Tetracycline lavage was associated with a significant overall reduction in postoperative infection rates in 25 of 74 patients (34 percent) receiving saline lavage compared with 15 of 85 patients (18 percent) having tetracycline lavage (P less than 0.05). Tetracycline lavage was associated with a significant reduction in the counts of aerobic and anaerobic bacteria in the peritoneal fluid at the end of the operation (P less than 0.05 and P less than 0.01, respectively) and with a significant reduction of aerobes 24 hours postoperatively (P less than 0.02). Tetracycline lavage would appear to confer clinical benefit in preventing postoperative infection.
No takes yet. Share an insight, caveat, or question.
Silverman et al. (1986) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: