Why the study?
Hypothermia can induce arrhythmia or ventricular fibrillation, but a complete assessment requires investigating both mechanophysiological and electrophysiological changes at the tissue level in human cells.
Does low temperature alter the electrophysiology and mechanophysiology of human induced pluripotent stem cell-derived cardiomyocytes?
Does low temperature alter the electrophysiology and mechanophysiology of human induced pluripotent stem cell-derived cardiomyocytes?
This study investigates the electrophysiological and mechanophysiological effects of low temperature on human induced pluripotent stem cell-derived cardiomyocytes to better understand hypothermia-induced arrhythmias.
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May inform hypothermia arrhythmia risk assessment; leaves open translation of integrated hiPSC-CM electro-mechanical data to clinical practice.
Studies related to low temperature and their effect on cardiomyocytes are essential as hypothermia—like situations have been known to induce arrhythmia or ventricular fibrillation. Till date, several studies have been carried out on animals and their electrophysiological responses have been studied in the form of action potential. However, for a complete assessment of the effect of low temperature, mechanophysiological changes along with electrophysiological changes need to be investigated, at the tissue level. In this study, the effect of culture temperature on cell growth has been studied by measuring the field potential and contractility of human induced pluripotent stem cell-derived cardiomyocytes. This study has the potential to further improve the understanding of low temperature on human cells.
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Kanade et al. (2021) studied this question.
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