Association of Diabetes and Endocrine Related Cancers in Turkish Balcova Heart Study Cohort

In this study we aimed to evaluate the association between diabetes and endocrine cancers in the Balçova Heart Disease Cohort. Methods The participants were indentified in a cardiovascular risk factor survey in İzmir, Turkey Balcova Heart Study (BHS). The baseline survey was conducted as a community screening programme from 2007 to 2009 in population over 30 years of age. Data on demographics, socioeconomic status and disease history were collected using a questionnaire. Diabetes definition was based on fasting blood glucose level ≥126 mg/dl and self-reported diabetes history. Data on incident cancer cases and patological types (pancreas, liver, breast, colorectal, urinary tract, and female reproductive organs) were obtained from the İzmir Cancer Registration Centre between the period of 2007 and 2014. Age adjusted odds ratios of cancer types for people with diabetes were calculated using logistic regression models. Results In total data from 10 375 women (65,4%) and 5494 men (34,6%) who did not declare any cancer in 2007 were evaluated. The incidence of endocrine cancers were 2293 per 100 000 in men and 1455 per 100 000 in women. The most common types of cancer were breast (810 per 100 000), colorectal (193 per 100 000) and uterus cancer (106 per 100 000) in women. In men prostate (1456 per 100 000), colorectal (346 per 100 000) and bladder (291 per 100 000) cancer were the most common cancer types. At the beginning of the study, 1643 (%10.4) people had diabetes. The age adjusted OR of having diabetes for overall endocrine cancers were 0.96 (95% CI: 068–1.37). The ORs for colorectal cancers was 0.63 (95% CI:0.22–1.79), for urogenital cancers (OR:0.90, 0.27–3.04), for breast cancer (OR: 0.84, 95% CI:0.42–1.71), for prostate cancer (OR: 1.25, 0.71–2.21), for liver cancer (OR:4.25, 0.92–19.63), for bladder cancer (OR:1.08, 0.37–3.22), Conclusion There was no statistically significant association between diabetes and endocrine related cancers in this seven years cohort study. The analyses can be repeated in the future, when the cohort gets older and more incident cases of cancers occur. Key message There was no statistically significant assocition between diabetes and endocrine related cancers