In vitro experiment demonstrates that anti-P1 antibodies reduce gliding speed and detach Mycoplasma pneumoniae, indicating that P1 adhesin conformational changes drive motility.
To examine the participation of P1 adhesin in gliding of Mycoplasma pneumoniae, we examined the effects of an anti-P1 monoclonal antibody on individual gliding mycoplasmas. The antibody reduced the gliding speed and removed the gliding cells from the glass over time in a concentration-dependent manner but had only a slight effect on nongliding cells, suggesting that the conformational changes of P1 adhesin and its displacement are involved in the gliding mechanism.
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Seto et al. (2005) studied this question.
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