Synthesis of new 4-(phenylamino)thieno[2,3-b]pyridines and derivatives of the novel benzo[b]thieno[3,2-h][1,6]naphthyridine tetracyclic system

Recently 1-hydroxyacridone derivatives were described as a new class of non-nucleoside inhibitors of Herpes Simplex Virus-1 (HSV-1), the agent of the most common human diseases. Based on these molecules, we applied rigid analogue and isosteric replacement approaches to design and synthesize five new benzo[b]thieno[3,2-h]-1,6-naphthyridines derivatives 8a-e as feasible anti-HSV prototypes. Herein we described the synthesis of this series of compounds and a theoretical evaluation of the drug score and drug likeness of these compounds by using an in silico ADMET screening.