Effects of Hypoxia and of Carbon Monoxide Exposures on Experimental Atherosclerosis

Editorial Notes1 August 1969Effects of Hypoxia and of Carbon Monoxide Exposures on Experimental AtherosclerosisPOUL ASTRUP, M.D.POUL ASTRUP, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-2-426 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor many years nicotine has been the focus of attention in discussions of the relation between tobacco smoking and development of arteriosclerosis, whereas carbon monoxide in the tobacco smoke has not been considered of pathogenetic importance. In animal experiments, nicotine has no atherogenic effect, yet exceptionally high concentrations of carboxyhemoglobin—for example, from 10 to 15%—have been found in smokers with early peripheral or coronary arteriosclerosis (1-3). The significance of this finding has been stressed by the enhancement of atheromatosis in cholesterol-fed rabbits exposed for 8 to 10 weeks to enough carbon monoxide to lead to a carboxyhemoglobin concentration of 15%...References1. ASTRUP P: Carbon monoxide and peripheral arterial disease. Scand. J. Clin. Lab. Invest. 19 (suppl. 99): 193, 1967. Google Scholar2. KJELDSEN K: Thesis. Munksgaard, Copenhagen, 1969. Google Scholar3. AYRESGIANELLIARMSTRONG SMSRG: Carboxyhemoglobin: hemodynamic and respiratory responses to small concentrations. Science 149: 193, 1965. CrossrefMedlineGoogle Scholar4. ASTRUPKJELDSENWANSTRUP PKJ: Enhancing influence of carbon monoxide on the development of atheromatosis in cholesterol-fed rabbits. J. Atheroscler. Res. 7: 343, 1967. CrossrefMedlineGoogle Scholar5. WANSTRUPKJELDSENASTRUP JKP: Acceleration of spontaneous intimal-subintimal changes in rabbit aorta by a prolonged moderate carbon monoxide exposure. Acta Path. Microbiol. Scand. 75: 353, 1969. MedlineGoogle Scholar6. KJELDSENWANSTRUPASTRUP KJP: Enhancing influence of arterial hypoxia on the development of atheromatosis in cholesterol-fed rabbits. J. Atheroscler. Res. 8: 835, 1968. CrossrefMedlineGoogle Scholar7. KJELDSENASTRUPWANSTRUP KPJ: Reversal of rabbit atheromatosis by hyperoxia. J. Atheroscler. Res. In press. Google Scholar8. CAMPBELL A: Comparison of the pathological effects of prolonged exposure to carbon monoxide with those produced by very low oxygen pressure. Brit. J. Exp. Path. 10: 304, 1929. Google Scholar9. ALTLANDHIGHMAN PDB: Acclimatization response of rats to discontinuous exposures to simulated high altitudes. Amer. J. Physiology 167: 261, 1951. CrossrefMedlineGoogle Scholar10. SIGGAARD-ANDERSENPETERSENHANSENMELLEMGAARD JFBTK: Plasma volume and vascular permeability during hypoxia and carbon monoxide exposure. Scand. J. Clin. Lab. Invest. 22 (suppl. 103): 39, 1968. CrossrefGoogle Scholar11. PAULITRUNIGERLARSENMULHAUSEN HGBJKRO: Renal function during prolonged exposure to hypoxia and carbon monoxide: I. Glomerular filtration and plasma flow. Scand. J. Clin. Lab. Invest. 22 (suppl. 103): 55, 1968. Google Scholar12. TRAP-JENSENLASSENKJELDSENKORSGAARDASTRUP JNKOP: Unpublished observations. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. 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HARRIS, M.D., MICHAEL W. ISBELL, STANLEY N. ROKAW, M.D., BRUNO IMPARATO, M.D.Heart Rate and Carbon Monoxide Level After Smoking High-, Low-, and Non-Nicotine Cigarettes A Study in Male Patients with Angina PectorisWlLBERT S. ARONOW, M.D., F.A.C.P., JAMES DENDINGER, B.S., STANLEY N. ROKAW, M.D. 1 August 1969Volume 71, Issue 2Page: 426-427KeywordsAtherosclerosisAttentionCarbon monoxideCarboxyhemoglobinHypoxiaNicotinePathogensRabbitsStable coronary artery disease Issue Published: 1 August 1969 PDF DownloadLoading ...