This meta-analysis organizes existing data on HV1 mutations to facilitate future research on the structure and function of the voltage-gated proton channel.
Organizes HV1 mutation data for swift access; extends prior characterizations across species for researchers.
The voltage-gated proton channel (HV1) is a widely distributed, proton-specific ion channel with unique properties. Since 2006, when genes for HV1 were identified, a vast array of mutations have been generated and characterized. Accessing this potentially useful resource is hindered, however, by the sheer number of mutations and interspecies differences in amino acid numbering. This review organizes all existing information in a logical manner to allow swift identification of studies that have characterized any particular mutation. Although much can be gained from this meta-analysis, important questions about the inner workings of HV1 await future revelation.
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DeCoursey et al. (2016) studied this question.
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