Neuropathologic Changes Associated With Experimental Anaphylaxis in the Monkey

Although pathologic investigations on various tissues and organs of animals subjected to experimental anaphylaxis have been numerous, only a few papers can be found in the literature on morphologic changes of the nervous system due to anaphylactic reactions. Two of these papers are concerned with the pathologic changes associated with the Arthus phenomenon in the brain. Davidoff, Seegal and Seegal,¹in rabbits prepared with multiple sensitizing injections of horse serum and shocked by one intracerebral injection, observed an extensive inflammatory lesion in the brain characterized by hemorrhage, edema, leukocytic infiltration and serum exudate. Alexander and Campbell²used a single intraperitoneal injection of horse serum in guinea pigs, followed by reinjection of the antigen intracerebrally. A lesion resulted characterized by "hemorrhage, vascular thrombosis, necrosis, demineralization, scavenger cells and reaction of microglia, oligodendroglia and astrocytes." These investigations leave little doubt as to the occurrence of a typical Arthus phenomenon in