July 1, 1994European Journal of BiochemistryOpen Access

Molecular cloning of low‐Ca2+‐sensitive‐type non‐muscle α‐actinin

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Population

Chicken lung lambda g11 cDNA library and various non-muscle tissues

Comparison

Molecular cloning and sequence analysis vs Other known alpha-actinins

Design

Preclinical

Authors

MIMichihiro ImamuraNational Center of Neurology and Psychiatry TSTakeshi SakuraiUniversity of Tsukuba YOYoshikatsu OgawaNational Institute of Advanced Industrial Science and Technology

Discussion

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Implication

Identifies a novel low-Ca2+-sensitive non-muscle alpha-actinin isoform; leaves open its functional relevance in mammalian systems.

Structured PICO

Population

Chicken lung lambda g11 cDNA library and various non-muscle tissues

Intervention

Molecular cloning and sequence analysis

Comparator

Other known alpha-actinins (chicken skeletal muscle, smooth-muscle, and fibroblast-type)

Outcome

Amino acid sequence identity and structural differencessurrogate

The study identifies a novel low-Ca2+-sensitive-type non-muscle alpha-actinin (NM2) in chicken lung, distinct from the high-Ca2+-sensitive-type (NM1), with structural differences in the Ca2+-binding EF-hand region explaining its lower Ca2+ sensitivity.

Cite This Study

Imamura et al. (1994) studied this question.

synapsesocial.com/papers/6a7058ca75498292b709c5c9 https://doi.org/10.1111/j.1432-1033.1994.tb19006.x

View Full Paper

Ask AI

Bookmark

Molecular cloning of low‐Ca2+‐sensitive‐type non‐muscle α‐actinin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Molecular cloning of low‐Ca2+‐sensitive‐type non‐muscle α‐actinin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider