Population
Rat alveolar epithelial cells
Comparison
Deuterium oxide (D2O) vs Water (H2O)
Design
Preclinical
Authors
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Animal proton channel data in D2O warrant no clinical translation; leaves open deprotonation mechanisms for human cardiovascular ion channels.
The study demonstrates that D+ interacts specifically with proton channels during permeation and suggests that H+ channel activation requires deprotonation of the channel.
DeCoursey et al. (1997) studied this question.
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