Key result
NOMAC-E2 use in an Italian cohort demonstrated high contraceptive effectiveness with a Pearl Index of 0.15 pregnancies per 100 women-years (95% CI 0.08-0.26).
Why the study?
To evaluate whether thromboembolic risk and contraceptive effectiveness of NOMAC-E2 observed in PRO-E2 extend across countries with differing lifestyles, cardiovascular risk factors, and prescribing habits.
Does the NOMAC-E2 combined oral contraceptive maintain low thromboembolic risk and high contraceptive effectiveness in an Italian cohort with a higher prevalence of older women and smokers?
Observational
Yes
Does the NOMAC-E2 combined oral contraceptive maintain low thromboembolic risk and high contraceptive effectiveness in an Italian cohort with a higher prevalence of older women and smokers?
In an Italian cohort with a higher prevalence of women over 35 and smokers, NOMAC-E2 demonstrated low thromboembolic risk and high contraceptive effectiveness.
PURPOSE: To evaluate whether the thromboembolic risk and contraceptive effectiveness of NOMAC-E2 observed in the PRO-E2 study can be extended to each participating country, as lifestyle, cardiovascular risk factors and prescribing habits may differ geographically. This analysis was performed on the PRO-E2 Italian subpopulation, where smoking habit and women over 35 years were more prevalent compared with the overall study population. MATERIALS AND METHODS: ) new users were descriptively analysed. Incidence rates of thrombosis (events/10,000 women-years [WY]) and the Pearl Index (pregnancies/100 WY) were calculated. RESULTS: (0.15/100 WY; 95% CI: 0.08-0.26) cohorts. CONCLUSION: . SHORT CONDENSATION: This subgroup analysis of the PRO-E2 study provides comprehensive epidemiological data on the use of combined oral contraceptives in a large Italian cohort, with a higher prevalence of women over 35 years and smokers. The study confirms the low thromboembolic risk and high contraceptive effectiveness of NOMAC-E2 pill.
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Fruzzetti et al. (2023) conducted an observational in Contraception. NOMAC-E2 was evaluated on Incidence rates of thrombosis (events/10,000 women-years) and the Pearl Index (pregnancies/100 women-years) (95% CI 0.08-0.26). NOMAC-E2 use in an Italian cohort demonstrated high contraceptive effectiveness with a Pearl Index of 0.15 pregnancies per 100 women-years (95% CI 0.08-0.26).
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