Electrocardiographic precordial mapping in anterior myocardial infarction. The critical period for interventions as exemplified by methylprednisolone.
Why the study?
Does methylprednisolone reduce the precordial area of Q waves at 24 hours in patients with acute uncomplicated anterior myocardial infarction?
Population
59 patients with acute uncomplicated anterior myocardial infarction (51 untreated, 8 treated)
Comparison
Methylprednisolone sodium succinate 25 mg/kg as… vs No methylprednisolone treatment
Design
Cohort
Follow-up
24 hours
Authors
Discussion
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Member takes
Implication
May limit early Q-wave evolution in anterior MI; hypothesis-generating and should not yet change practice.
Structured PICO
Does methylprednisolone reduce the precordial area of Q waves at 24 hours in patients with acute uncomplicated anterior myocardial infarction?
P
Population
59 patients with acute uncomplicated anterior myocardial infarction (51 untreated, 8 treated)
I
Intervention
Methylprednisolone sodium succinate 25 mg/kg as a single intravenous injection within 6 hours from the onset of chest pain
C
Comparator
No methylprednisolone treatment (natural history cohort)
O
Outcome
Precordial area of Q waves at 24 hourssurrogate
Early administration of methylprednisolone in acute anterior myocardial infarction may reduce the extent of infarction as assessed by precordial Q wave mapping.
Cite This Study
Selwyn et al. (1978) studied this question.