Key result
The severity of lower urinary tract symptoms in men with benign prostatic hyperplasia was significantly correlated with the atherogenic index of plasma (r=0.388) and negatively correlated with heart rate recovery (r=-0.547).
Why the study?
Cardiovascular diseases are highly prevalent in benign prostatic hyperplasia patients, motivating the evaluation of cardiovascular metabolic and autonomic predictors in relation to lower urinary tract symptom severity.
Cross-Sectional (n=318)
No
Answers are grounded in this paper and cite their sources.
In patients with benign prostatic hyperplasia, the severity of lower urinary tract symptoms correlates with metabolic and autonomic parameters that predict an increased risk of cardiovascular disease.
OBJECTIVES: High prevalence of cardiovascular diseases is present in benign prostatic hyperplasia patients. Risk prediction models were developed for early identification of these cardiovascular risks. We aimed to evaluate cardiovascular metabolic and autonomic predictors in relation to lower urinary tract symptoms' severity evaluated by the IPSS score. METHODS: This study included 318 healthy individuals recently diagnosed with BPH. Laboratory tests including metabolic, hormonal and inflammatory markers were recorded. The cardiovascular risk indices like the atherogenic index of plasma and the triglyceride glucose index were calculated. The heart rate recovery after graded exercise was calculated. RESULTS: There was a significant positive correlation between the IPSS score and both the atherogenic and the triglyceride glucose indices (r = 0.388, p < 0.01 and r = 0.109, p = 0.032, respectively). IPSS score was also significantly negatively correlated with heart rate recovery specially at the 3rd minute after exercise (r = -0.547, p < 0.01). On the other hand, the IPSS score had a significant positive correlation with the inflammatory markers and a significant negative correlation with serum testosterone levels. CONCLUSIONS: Our study results suggest the presence of a combination of hormonal and inflammatory changes in BPH patients affecting the severity of LUTS which is correlated with metabolic and autonomic parameters that can predict an increased risk of CVD (Tab. 3, Ref. 47).
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Koçak et al. (2022) conducted a cross-sectional in Benign prostatic hyperplasia (n=318). Lower urinary tract symptoms (IPSS score) was evaluated on Correlation between IPSS score and atherogenic index of plasma (AIP) (r=0.388, p=<0.01). The severity of lower urinary tract symptoms in men with benign prostatic hyperplasia was significantly correlated with the atherogenic index of plasma (r=0.388) and negatively correlated with heart rate recovery (r=-0.547).
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