Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors

Figures

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  Fig. 1. Polygenic overlap between neuroticism (NEUR) conditioned on CAD (NEUR∣CAD) and CAD conditioned on NEUR (CAD∣NEUR). Conditional q–q plots of nominal versus empirical –log 10p values (corrected for inflation) in primary trait (NEUR or CAD) below the standard GWAS threshold of P < 5 × 10–8 as a function of significance of association with secondary trait (CAD or NEUR) at the level of P < 0.1, P < 0.01, and P < 0.001, respectively. The blue line indicates all SNPs. The dashed line indicate the null hypothesis.

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  Fig. 2. Polygenic overlap between neuroticism (NEUR) conditioned on BMI (NEUR∣BMI) and BMI conditioned on NEUR (BMI∣NEUR). Conditional q–q plots of nominal versus empirical –log 10p values (corrected for inflation) in primary trait (NEUR or BMI) below the standard GWAS threshold of p < 5 × 10–8 as a function of significance of association with secondary trait (BMI or NEUR) at the level of p < 0.1, p < 0.01, and p < 0.001, respectively. The blue line indicates all SNPs. The dashed line indicate the null hypothesis.

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  Fig. 3. Common genetic variants jointly associated with neuroticism (n = 432,109) and CAD (n = 184,305) at conjunctional false discovery rate (conjFDR) < 0.05. Manhattan plot showing the –log10 transformed conjFDR values for each SNP on the y axis and the chromosomal positions along the x axis. The dotted horizontal line represents the threshold for significant shared associations (conjFDR < 0.05, i.e., −log10(conjFDR) > 2.0). Independent lead SNPs are encircled in black. The significant shared signal in the major histocompatibility complex region (chr6:25119106–33854733) is represented by one independent lead SNP. Further details are available in Supplementary Table 2.

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  Fig. 4. Common genetic variants jointly associated with neuroticism (n = 432,109) and BMI (n = 184,305) at conjunctional false discovery rate (conjFDR) < 0.05. Manhattan plot showing the –log10 transformed conjFDR values for each SNP on the y axis and the chromosomal positions along the x axis. The dotted horizontal line represents the threshold for significant shared associations (conjFDR < 0.05, i.e., −log10(conjFDR) > 2.0). Independent lead SNPs are encircled in black. The significant shared signal in the major histocompatibility complex region (chr6:25119106–33854733) is represented by one independent lead SNP. Further details are available in Supplementary Table 3.