Key result
The J-Valve system demonstrated a 96% procedural success rate in Chinese patients with severe aortic regurgitation, though a significant incidence of complications persists.
Why the study?
This meta-analysis aimed to evaluate the efficacy and safety of the J-valve system in patients with aortic regurgitation.
Meta-Analysis (n=552)
The J-Valve prosthesis demonstrates high procedural success (96%) and favorable short-term mortality in Chinese patients with severe aortic regurgitation, though complication rates remain notable.
May support J-Valve for severe AR; leaves open need for randomized trials on complications and generalizability.
Objective: This meta-analysis aimed to evaluate the efficacy and safety of J-valve in patients with Aortic regurgitation (AR). Methods: PubMed, Embase, the Cochrane Library, and Web of Science databases were searched from inception to November 2024. Primary outcome included Procedural Success, and secondary outcome included In-Hospital Mortality, 30-Day Mortality, One-Year All-Cause Mortality, Stroke Incidence and Complications. The risk of bias was assessed by subgroup analysis, sensitivity analysis, and publication bias, including funnel plot, Egger's test, and Begg's test. Results: A total of 9 studies involving 552 patients were included in this meta-analysis. The results indicated a surgical success rate of 96% (95% CI: 0.94-0.99). The in-hospital mortality rate was 3% (95% CI: 0.01-0.04), the 30-day mortality rate was 3% (95% CI: 0.01-0.05), and the 1-year all-cause mortality rate was 6% (95% CI: 0.04-0.08). Additionally, the incidence of stroke was 2% (95% CI: 0.01-0.03), and the incidence of other complications was 22% (95% CI: 0.16-0.28). Conclusions: This meta-analysis indicates that the J-Valve prosthesis exhibits favorable short-term efficacy in patients with severe aortic regurgitation (AR); however, a significant incidence of complications persists. A thorough risk assessment is crucial when determining the appropriate treatment strategy. Furthermore, postoperative follow-up duration should be extended to monitor patient outcomes effectively. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024552406, identifier CRD42024552406.
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Gao et al. (2025) conducted a meta-analysis in Aortic regurgitation (n=552). J-Valve system was evaluated on Procedural Success (96%, 95% CI 0.94-0.99). The J-Valve system demonstrated a 96% procedural success rate in Chinese patients with severe aortic regurgitation, though a significant incidence of complications persists.
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