Key result
The COSMIC-19 study is a methodology protocol aiming to recruit 50 patients with COVID-19 to evaluate cardiovascular pathology using multimodality imaging and its association with troponin levels.
Why the study?
Cardiac injury is common and associated with adverse prognosis in COVID-19, but the cardiovascular mechanisms of injury are poorly understood and speculative.
Does multimodality cardiac imaging identify the cardiac pathophysiological mechanisms related to COVID-19 infections?
Observational (n=50)
No
Does multimodality cardiac imaging identify the cardiac pathophysiological mechanisms related to COVID-19 infections?
This methodology paper describes a prospective observational study to identify cardiovascular mechanisms of injury in COVID-19 using multimodality imaging.
Offers no immediate clinical guidance; leaves open whether multimodality imaging links troponin elevation to cardiac pathology in COVID-19.
Background: 8-28% of patients infected with COVID-19 have evidence of cardiac injury, and this is associated with an adverse prognosis. The cardiovascular mechanisms of injury are poorly understood and speculative. We aim to use multimodality cardiac imaging including cardiac magnetic resonance (CMR) imaging, computed tomography coronary angiography (CTCA) and positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro- D-glucose integrated with computed tomography (18F-FDG-PET/CT) to identify the cardiac pathophysiological mechanisms related to COVID-19 infections. Methods: This is a single-centre exploratory observational study aiming to recruit 50 patients with COVID-19 infection who will undergo cardiac biomarker sampling. Of these, 30 patients will undergo combined CTCA & 18F-FDG-PET/CT, followed by CMR. Prevalence of obstructive and non-obstructive atherosclerotic coronary disease will be assessed using CTCA. CMR will be used to identify and characterise myocardial disease including presence of cardiac dysfunction, myocardial fibrosis, myocardial oedema and myocardial infarction. 18F-FDG-PET/CT will identify vascular and cardiac inflammation. Primary endpoint will be the presence of cardiovascular pathology and the association with troponin levels. Discussion: The results of the study will identify the presence and modality of cardiac injury associated COVID-19 infection, and the utility of multi-modality imaging in diagnosing such injury. This will further inform clinical decision making during the pandemic. TRIAL REGISTRATION : This study has been retrospectively registered at the ISRCTN registry (ID ISRCTN12154994) on 14th August 2020. Accessible at www.isrctn.com/ISRCTN12154994
No takes yet. Share an insight, caveat, or question.
Alam et al. (2021) conducted an observational in COVID-19 infection (n=50). Multimodality cardiac imaging was evaluated on Presence of cardiovascular pathology and the association with troponin levels. The COSMIC-19 study is a methodology protocol aiming to recruit 50 patients with COVID-19 to evaluate cardiovascular pathology using multimodality imaging and its association with troponin levels.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: