Long-term heparin prophylaxis during pregnancy may cause severe hypertriglyceridaemia due to lipoprotein lipase deficiency.
May warrant triglyceride monitoring with prolonged heparin in pregnancy; single case leaves open causality and prevalence of LPL effects.
A case of severe hypertriglyceridaemia presenting in the third trimester of pregnancy in a woman on long-term heparin prophylaxis is described. The hypertriglyceridaemia was attributed to impaired clearance of triglyceride-rich lipoprotein particles secondary to heparin-induced reduction in the activity of the lipolytic enzyme, lipoprotein lipase.
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Watts et al. (1991) studied this question.
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