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A DNA-encoded macrocyclic peptide library was designed and synthesized with 2.4 × 10 12 members composed of 4–20 natural and non-natural amino acids. Affinity-based selection was performed against two therapeutic targets, VHL and RSV N protein. On the basis of selection data, some peptides were selected for resynthesis without a DNA tag, and their activity was confirmed.
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Zhu et al. (2017) studied this question.
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