Key result
New oral anticoagulants offer an alternative to enoxaparin for preventing thrombosis post orthopedic surgery, with considerations for pharmacology, efficacy, and patient convenience.
Why the study?
Do new oral anticoagulants offer improved convenience and a favorable risk-benefit profile compared to enoxaparin for thrombus prevention in post-orthopedic surgery patients?
Do new oral anticoagulants offer improved convenience and a favorable risk-benefit profile compared to enoxaparin for thrombus prevention in post-orthopedic surgery patients?
This review provides a practical guide and recommendations for the use of new oral anticoagulants in post-orthopedic surgery patients, highlighting their convenience and risk-benefit profile compared to enoxaparin.
Answers are grounded in this paper and cite their sources.
May support new oral anticoagulants as enoxaparin alternatives post-orthopedic surgery; leaves open need for updated randomized comparisons.
Anticoagulant therapy is essential for the prevention of risks associated with the formation of thrombus in patients after surgery, especially in orthopedics. Recently, new oral anticoagulants were introduced in the therapeutic arsenal. This fact is important, because the current drug of choice in clinical practice is enoxaparin, a low molecular weight heparin. As all injecting drugs, enoxaparin may reduce patients' adherence to treatment by dissatisfaction with and resistance to the administration. This article reviews the available literature on the overall utility of these innovative medicines, approaching the pharmacology, the compared efficacy in relation to current agents, and the potential targets for new agents, as well as points to new trends in research and development. The article also contributes with a practical guide for use and recommendations to health professionals, especially focusing on the reversibility of hemorrhagic events, and discusses the importance of convenience/satisfaction of use, the cost of treatment, and the risk-benefit profile for patients.
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Kropf et al. (2011) conducted a review in post orthopedic surgery. new oral anticoagulants vs. enoxaparin was evaluated. New oral anticoagulants offer an alternative to enoxaparin for preventing thrombosis post orthopedic surgery, with considerations for pharmacology, efficacy, and patient convenience.
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