The relationship of silver sulfadiazine therapy to leukopenia has been controversial. In our burn unit the incidence of leukopenia increased dramatically in 1978. Leukopenia was observed only in silver sulfadiazine-treated patients and not in patients treated with other agents. Because cimetidine had been introduced at about that time, the possibility of a drug interaction was investigated with a prospective randomized study. It was found that leukopenia continued to appear in a large percentage of patients in both groups, although the incidence was higher in cimetidine-treated patients.
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Caffee et al. (1982) studied this question.