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A simple high-performance liquid chromatographic method for the determination of nifedipine, dimethyl 1, 4-dihydro-2, 6-dimethyl-4-(2-nitrophenyl)-3, 5-pyridinedicarboxylate, in plasma is described. The method permits the accurate determination of the drug in plasma at concentrations as low as 2 ng/ml and is suitable for drug monitoring and for investigation of the bioavailabilities of drug preparations.
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Sadanaga et al. (1982) studied this question.
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